Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology RSS feed: Current Issue. The Journal is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for four societies, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology , is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library. The Journal is ranked 37th for impact factor out of 77 Dentistry, Oral Surgery and Medicine titles on the 2010 Journal Citation ReportsÂ®, published by Thomson Reuters. It is the highest ranked Oral and Maxillofacial Surgery title by number of citations.
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Mitogen-activated protein kinase (MAPK) pathways are evolutionarily conserved kinase modules that link extracellular signals to the machinery that controls fundamental cellular processes such as growth, proliferation, differentiation, migration, and apoptosis. Constitutive activation of the signal transducer and activator of transcription 3 (Stat3) signaling pathway has been associated with oncogenic potential in oral squamous cell carcinoma (OSCC). The effects of MAPKs and especially extracellular signal-regulated kinase (ERK) activation on Stat3 signaling in OSCC is not thoroughly investigated. Our purpose was to examine the hypothesis that Erka/2 activity modulates Stat3 signaling and cellular activities in OSCC cells.
Desmoglein (Dsg) is overexpressed in head and neck squamous cell carcinoma (SCC) and is thought to be a biomarker for diagnosis and treatment. We developed a method of targeting antitumor agent to the epidermis by using anti-Dsg single chain variable fragment (scFv) antibody for oral cancer treatment.
Despite the great clinical benefits of bisphosphonates, a severe complication known as bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been reported. Although most studies confirmed that invasive dental procedures are the main causes of BRONJ, around 30% of BRONJ occurred spontaneously. This study aimed to investigate the role of progressive periodontal disease in inducing BRONJ using an ovariectomized rat model.
A cost-of-illness study can provide an estimate of the economic effect of a disease on society. It can therefore inform policy makers in planning the delivery and financing of health services. The objective of this pilot study is to assess the economic burden of oral lichen planus (OLP) from the perspective of the health care provider in a UK population.
The aim of this study was to investigate the use of and acquaintance with guidelines on medication prescription of Dutch dentists and their actual prescribing of medication to their patients.
To assess the efficacy of betamethasone in combination with hyaluronidase on oral submucous fibrosis (OSF) patients in a randomized controlled trial. Sixty OSF patients were randomly divided into group A (receiving 10 bilateral injections of betamethasone and hyaluronidase weekly for 10 weeks) and group B (receiving placebo injections). Betamethasone was supplied as injection betamethasone sodium phosphate 4 mg/mL (Glaxo SmithKline pharmaceuticals, India). Randomization was performed by using a block size of 6 with an allocation ratio of 2:1. Mouth opening, burning sensation, and quality of life (QOL) assessment were done using repeated-measures analysis of covariance (RM ANCOVA) and ANCOVA tests for intragroup and intergroup comparisons.
In the present study, 2 scoring systems, 1 proposed by Pibooniyyom et al. (designated REU) and 1 proposed by Thongprasom et al. (designated WEA), were used for the evaluation of oral lichen planus (OLP) lesions. The aim of the study was to assess the reproducibility and the learning curve of both systems, according to evaluations made by 3 different raters.
A wide range of placebo responses has been documented in randomized controlled trials (RCTs) evaluating treatment efficacy in burning mouth syndrome (BMS). Given the subjective nature of BMS symptoms and the subsequent reliance on patient-reported outcomes, a better understanding of the placebo effect in BMS is critical in the assessment of treatment response and in the design of future RCTs. The objective of this study was to evaluate the placebo effect in published RCTs of therapies for BMS.
Oral chronic graft-vs-host disease (cGVHD) is a frequent and potentially debilitating complication after allogeneic hematopoietic cell transplant (HCT). Despite the overall effectiveness of topical immunosuppressive therapies (IST), there continues to be a need for novel and alternative therapies. The objective of this study was to evaluate the safety and efficacy of intraoral narrow-band UV-B (NB-UV-B) phototherapy in the management of oral cGVHD.
The onset of osteonecrosis of the jaws (ONJ) is often preceded by tooth extraction or other trauma. The purpose of the present study was to examine the frequency of oral trauma preceding the onset of ONJ, as well as the characteristics of the patients in a cohort of patients with ONJ.
To investigate the incidence and clinical significance of perianal disease in association with orofacial granulomatosis (OFG). A proportion of patients with OFG present with concurrent perianal disease. Perianal disease is common in Crohn disease (CD) and often associated with a more severe disease course and a significant morbidity.
We developed a new electronic device for sialometry of minor salivary glands (Oral Surg Oral Med Oral Pathol Oral Radiol 2013;116:301-305). The purpose of this study was to compare labial gland secretion rates (LGSRs) of patients with Sjögren syndrome (SS) and of healthy control participants by using the electronic device.
To assess trends in oral squamous cell carcinoma (OSCC) diagnoses in a UK oral medicine unit over a 9-year period. The study examined OSCC incidence annually, as well as the demographic data of patients diagnosed over this period.
Primary chronic osteomyelitis (PCO) is a rare nonsuppurative inflammatory disease of unknown etiology presenting as intermittent episodes of mandibular pain, swelling, regional lymphadenopathy, and trismus. It usually presents with diffuse, unilateral enlargement of the mandible, runs a chronic clinical course, and is often refractory to antibiotic treatment.
Clonazepam is effective against burning mouth syndrome but has multiple side effects. The most frequently reported are neurologic (central nervous system inhibition) then dermatologic. Mucosal side effects are unknown. We hereby present a case with oral bullous eruptions related to clonazepam use.
Paraneoplastic pemphigus (PNP) is a mucocutaneous disease commonly associated with lymphoproliferative neoplasms. A 55-year-old man presented with widespread oral mucosal lesions of 2 months' duration. The patient was previously evaluated and underwent 2 oral biopsies consistent with lichen planus. Review of systems was positive for dysphagia, dyspnea, and wheezing. Clinical examination found widespread ulceration of the oral mucosa and the left inner eye canthus. Diagnosis was consistent with erosive lichen planus. Treatment of the oral lesions consisted of topical and systemic corticosteroids, and the patient was referred to ophthalmology, dermatology, and otorhinolaryngology for associated findings. On reevaluation, the patient reported improvement of oral symptoms, and clinical examination found slowly healing ulcerations on involved oral mucosal surfaces. On subsequent follow-up, the patient reported undergoing repeat oral biopsy consistent with a nonspecific ulcer and a negative direct immunofluorescence study. In addition, a biopsy of the left eye inner canthus was consistent with lichenoid dermatitis. Despite these findings, the diagnosis of lichen planus was reconsidered owing to ongoing pulmonary symptoms, because PNP is associated with bronchiolitis obliterans. Indirect immunofluorescence study and enzyme-linked immunosorbent assay for desmoglein-1 and -3 were performed and found positive cell surface staining on monkey esophagus and the presence of anti-desmoglein-3 antibodies, suggestive either of pemphigus vulgaris or PNP. The patient was referred to pulmonology. Pulmonary function tests found very severe obstructive disease, and a computed tomography scan of the chest and abdomen found air trapping, as seen in bronchiolitis obliterans, as well as retroperitoneal lymphadenopathy extending from the aortic bifurcation to the level of the renal vein. A left preaortic lymph node biopsy was consistent with follicular lymphoma, supporting the diagnosis of PNP.
Fluorodeoxyglucose-labeled positron emission tomography (FDG-PET) has shown a high diagnostic value for identifying lymph node metastasis over contrast-enhanced computed tomography (CT) in many oncologic fields. This study evaluated the diagnostic accuracy of FDG-PET/CT in comparison with histologic findings for detecting metastatic cervical lymph nodes in patients with oral cancer.
Tobacco use and alcohol consumption have been related to the majority of oral cancers. Candida, an opportunistic fungal pathogen, has been implicated in oral and esophageal cancers. This study aimed to isolate, identify, and genotype Candida isolates from 52 patients with oral cancer and from 104 age-, gender-, and denture status–matched participants without oral cancer.
To determine the practice characteristics of American Academy of Oral Medicine (AAOM) diplomates who provide oral health care in North America. An institutional review board–approved survey was distributed electronically and during 2 annual scientific meetings to all active members of AAOM between March 2011 and June 2012. Participants were asked to record patient information (i.e., demographic data, diagnosis, referral source, location) for a 5-day practice week. Data were analyzed with descriptive statistics and bivariate analysis to explore the association between systemic disease and oral medicine diagnoses.
The purpose of this study was to investigate how xylitol and sorbitol could affect the enzymatic and candidacidal activities of lysozyme, the peroxidase system, and the glucose oxidase–mediated peroxidase system.