Faculty Bibliography Search Results

"The role of Langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs. 1976"

MEDL:2649607  #16109    

Evidence in favor of a role for Langerhans cells in contact allergic hypersensitivity reactions has been reviewed. This includes mononuclear cell to Langerhans cell apposition and damage to some Langerhans cells at sites of specific challenge to a variety of contact allergens. Such apposition occurs in actively sensitized patients and guinea pigs and in passively sensitized guinea pigs. In addition, in passively sensitized guinea pigs, Langerhans cells circulate in dermal vessels resembling lymphatics and are much increased in the dermis after challenge with the contact allergen. These observations, together with the existing knowledge that Langerhans cells occur in the lymph nodes and thymus, suggest that these cells may be involved not only in contact allergic reactions but also in other immunologic reactions, particularly in cell-mediated reactions in the skin.

"Langerhans cells are target cells in contact hypersensitivity"

MEDL:3487987  #16111    

"Langerhans cells : a review of their nature with emphasis on their immunologic functions"

"Langerhans cells: role in contact hypersensitivity and relationship to lymphoid dendritic cells and to macrophages"

MEDL:7009405  #8890    

GRANTS:AM 26091/AM/NIADDK NIH HHS/United States

"Contact hypersensitivity and Langerhans cells"

MEDL:7391610  #8884    

Allergens or antigens when introduced on or in the skin may become localized at the surface of and in Langerhans cells (LCs). Langerhans cells are a strategically situated cell population able to migrate into lymphatics and lymph nodes. During the course of contact allergic reactions, they are apposed to lymphocytes; some LCs are injured by interaction with lymphocytes and by antigen-antibody complexes plus complement. It is not yet clear to what extent these LCs may then release the substances they contain, such as enzymes from lysosomes, and cause further inflammatory changes. In contact dermatitis they appear to play the role of antigen presenters, and may also be target cells and inflammation-producing cells. Since in contact allergy the major antigen presentation occurs via skin, it is likely that the presence of functional LCs with intact Ia antigens is of paramount importance for induction and elicitation of this immune response..

"The Langerhans Cells"

"Langerhans cells as macrophages in skin and lymphoid organs"

MEDL:6993584  #8885    

Properties of epidermal Langerhans cell were compared with those of a number of other dendritic cells in lymphoid organs and of mononuclear phagocytes. Among the dendritic 'reticulum' cells included were indeterminate cells from the epidermis, interdigitating 'reticulum' cells from T-dependent areas of lymphoid tissue and thymus, follicular dendritic cells of Nossal, and the dendritic cells described by Steinman and Cohn. Interdigitating cells with typical Birbeck granules, in the thymus and in the paracortices of lymph nodes, which are morphologically indistinguishable from Langerhans cells and indeterminate dendritic cells in the epidermis, appear to belong to the same system and possibly represent a subpopulation of 'macrophages.' On the basis of their similarity to these other dendritic cells, we believe Langerhans cells may function in antigen presentation, lymphokine production, provision of a microenvironment for T lymphocytes, and prostaglandin secretion.

"Langerhans cells: a review of their nature with emphasis on their immunologic functions"

MEDL:351630  #8912    

"On Langerhans cells"

MEDL:914409  #63379    

"Langerhans cells: target cells in immune complex reactions"

MEDL:71214  #8915    

"LANGERHANS CELLS - TARGET-CELLS IN IMMUNE-COMPLEX REACTIONS" [Meeting Abstract]

ISI:A1977DB15800518  #29592    

"The role of Langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs"

MEDL:774995  #16135    

Evidence in favor of a role for Langerhans cells in contact allergic hypersensitivity reactions has been reviewed. This includes mononuclear cell to Langerhans cell apposition and damage to some Langerhans cells at sites of specific challenge to a variety of contact allergens. Such apposition occurs in actively sensitized patients and guinea pigs and in passively sensitized guinea pigs. In addition, in passively sensitized guinea pigs Langerhans cells circulate in dermal vessels resembling lymphatics and are much increased in the dermis after challenge with the contact allergen. These observations, together with the existing knowledge that Langerhans cells occur in the lymph nodes and thymus, suggest that these cells may be involved not only in contact allergic reactions but also in other immunologic reactions, particularly in cell-mediated reactions in the skin.

"Antigen-bearing langerhans cells in skin, dermal lymphatics and in lymph nodes"

MEDL:782728  #8924    

"ANTIGEN-BEARING LANGERHANS CELLS IN DERMAL LYMPHATICS AND IN LYMPH-NODES" [Meeting Abstract]

ISI:A1976BU02800614  #29462    

"ANTIGEN-BEARING LANGERHANS CELLS IN DERMAL LYMPHATICS AND IN LYMPH-NODES" [Meeting Abstract]

ISI:A1976BU02801751  #29468    

"ANTIGEN-BEARING LANGERHANS CELLS IN DERMAL LYMPHATICS AND IN LYMPH-NODES" [Meeting Abstract]

ISI:A1976BN06400073  #29483    

"Dermal and intravascular Langerhans cells at sites of passively induced allergic contact sensitivity"

MEDL:1139641  #8936    

"LANGERHANS CELLS IN SKIN, LYMPHATIC-LIKE VESSELS AND DRAINING LYMPH-NODES IN ALLERGIC CONTACT SENSITIVITY" [Meeting Abstract]

ISI:A1975W188500380  #28654    

"Circulating Langerhans cells in a dermal vessel"

MEDL:4133025  #16139    

"The role of langerhans cells in contact allergy. I. An ultrastructural study in actively induced contact dermatitis in guinea pigs"

MEDL:4138800  #16138