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Silberberg-Sinakin, Inga

silbei01
NYU School of Medicine,  1963-1976

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Citations 1 - 20 of 35
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1.

"The role of Langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs. 1976"

SILBERBERG I; Baer RL; Rosenthal SA
Journal of investigative dermatology 1989 Apr;92(4 Suppl):160S; discussion 161S-160S; discussion 163S
MEDL:2649607  #16109  Click here for full text  

Evidence in favor of a role for Langerhans cells in contact allergic hypersensitivity reactions has been reviewed. This includes mononuclear cell to Langerhans cell apposition and damage to some Langerhans cells at sites of specific challenge to a variety of contact allergens. Such apposition occurs in actively sensitized patients and guinea pigs and in passively sensitized guinea pigs. In addition, in passively sensitized guinea pigs, Langerhans cells circulate in dermal vessels resembling lymphatics and are much increased in the dermis after challenge with the contact allergen. These observations, together with the existing knowledge that Langerhans cells occur in the lymph nodes and thymus, suggest that these cells may be involved not only in contact allergic reactions but also in other immunologic reactions, particularly in cell-mediated reactions in the skin.


2.

"Langerhans cells are target cells in contact hypersensitivity"

SILBERBERG-SINAKIN I; Baer RL
American journal of dermatopathology 1986 Jun;8(3):230-231
MEDL:3487987  #16111  Click here for full text  10.1097/00000372-198606000-00008

3.

"Langerhans cells : a review of their nature with emphasis on their immunologic functions"

SILBERBERG-SINAKIN I; Baer RL; Thorbecke GJ
IN: A reminiscent festscrift on the centenary of the Skin and Cancer Unit of the Department of Dermatology of the New York University / Leider M (Ed.)New York : NYU School of Medicine, 1983 p.233-259
ORIGINAL:0001895  #3006  

4.

"Langerhans cells: role in contact hypersensitivity and relationship to lymphoid dendritic cells and to macrophages"

SILBERBERG-SINAKIN I; Gigli I; Baer RL; Thorbecke GJ
Immunological reviews 1980 ;53:203-232
MEDL:7009405  #8890  Click here for full text  10.1111/j.1600-065X.1980.tb01045.x

GRANTS:AM 26091/AM/NIADDK NIH HHS/United States


5.

"Contact hypersensitivity and Langerhans cells"

SILBERBERG-SINAKIN I; Thorbecke GJ
Journal of investigative dermatology 1980 Jul;75(1):61-67
MEDL:7391610  #8884  Click here for full text  10.1111/1523-1747.ep12521144

Allergens or antigens when introduced on or in the skin may become localized at the surface of and in Langerhans cells (LCs). Langerhans cells are a strategically situated cell population able to migrate into lymphatics and lymph nodes. During the course of contact allergic reactions, they are apposed to lymphocytes; some LCs are injured by interaction with lymphocytes and by antigen-antibody complexes plus complement. It is not yet clear to what extent these LCs may then release the substances they contain, such as enzymes from lysosomes, and cause further inflammatory changes. In contact dermatitis they appear to play the role of antigen presenters, and may also be target cells and inflammation-producing cells. Since in contact allergy the major antigen presentation occurs via skin, it is likely that the presence of functional LCs with intact Ia antigens is of paramount importance for induction and elicitation of this immune response..


6.

"The Langerhans Cells"

SILBERBERG-SINAKIN, I.; Thorbecke, G.J
IN: Reticuloendothelial system : a comprehensive treatise : morphology / I. Carr and W.T Daems (eds)New York : Plenum Press, 1980 p.555-605
ORIGINAL:0001498  #2503  

7.

"Langerhans cells as macrophages in skin and lymphoid organs"

Thorbecke GJ; SILBERBERG-SINAKIN I; Flotte TJ
Journal of investigative dermatology 1980 Jul;75(1):32-43
MEDL:6993584  #8885  Click here for full text  10.1111/1523-1747.ep12521083

Properties of epidermal Langerhans cell were compared with those of a number of other dendritic cells in lymphoid organs and of mononuclear phagocytes. Among the dendritic 'reticulum' cells included were indeterminate cells from the epidermis, interdigitating 'reticulum' cells from T-dependent areas of lymphoid tissue and thymus, follicular dendritic cells of Nossal, and the dendritic cells described by Steinman and Cohn. Interdigitating cells with typical Birbeck granules, in the thymus and in the paracortices of lymph nodes, which are morphologically indistinguishable from Langerhans cells and indeterminate dendritic cells in the epidermis, appear to belong to the same system and possibly represent a subpopulation of 'macrophages.' On the basis of their similarity to these other dendritic cells, we believe Langerhans cells may function in antigen presentation, lymphokine production, provision of a microenvironment for T lymphocytes, and prostaglandin secretion.


8.

"Langerhans cells: a review of their nature with emphasis on their immunologic functions"

SILBERBERG-SINAKIN I; Baer RL; Thorbecke GJ
Progress in allergy 1978 ;24:268-294
MEDL:351630  #8912  Click here for full text  

9.

"On Langerhans cells"

SILBERBERG-SINAKIN I
International journal of dermatology 1977 Sep;16(7):581-583
MEDL:914409  #63379  Click here for full text  10.1111/j.1365-4362.1977.tb00784.x

10.

"Langerhans cells: target cells in immune complex reactions"

SILBERBERG-SINAKIN I; Fedorko ME; Baer RL; Rosenthal SA; Berezowsky V; Thorbecke GJ
Cellular immunology 1977 Aug;32(2):400-416
MEDL:71214  #8915  Click here for full text  10.1016/0008-8749(77)90216-7

11.

"LANGERHANS CELLS - TARGET-CELLS IN IMMUNE-COMPLEX REACTIONS" [Meeting Abstract]

SILBERBERGSINAKIN, I; Fedorko, ME; Baer, RL; Rosenthal, SA; Berezowsky, V; Thorbecke, GJ
Clinical research 1977 ;25(3):A287-A287
ISI:A1977DB15800518  #29592  Click here for full text  

12.

"The role of Langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs"

SILBERBERG I; Baer RL; Rosenthal SA
Journal of investigative dermatology 1976 Apr;66(4):210-217
MEDL:774995  #16135  Click here for full text  10.1111/1523-1747.ep12482139

Evidence in favor of a role for Langerhans cells in contact allergic hypersensitivity reactions has been reviewed. This includes mononuclear cell to Langerhans cell apposition and damage to some Langerhans cells at sites of specific challenge to a variety of contact allergens. Such apposition occurs in actively sensitized patients and guinea pigs and in passively sensitized guinea pigs. In addition, in passively sensitized guinea pigs Langerhans cells circulate in dermal vessels resembling lymphatics and are much increased in the dermis after challenge with the contact allergen. These observations, together with the existing knowledge that Langerhans cells occur in the lymph nodes and thymus, suggest that these cells may be involved not only in contact allergic reactions but also in other immunologic reactions, particularly in cell-mediated reactions in the skin.


13.

"Antigen-bearing langerhans cells in skin, dermal lymphatics and in lymph nodes"

SILBERBERG-SINAKIN I; Thorbecke GJ; Baer RL; Rosenthal SA; Berezowsky V
Cellular immunology 1976 Aug;25(2):137-151
MEDL:782728  #8924  Click here for full text  10.1016/0008-8749(76)90105-2

14.

"ANTIGEN-BEARING LANGERHANS CELLS IN DERMAL LYMPHATICS AND IN LYMPH-NODES" [Meeting Abstract]

SILBERBERGSINAKIN, I; Thorbecke, GJ; Baer, RL; Rosenthal, SA; Berezowsky, V
Clinical research 1976 ;24(3):A267-A267
ISI:A1976BU02800614  #29462  Click here for full text  

15.

"ANTIGEN-BEARING LANGERHANS CELLS IN DERMAL LYMPHATICS AND IN LYMPH-NODES" [Meeting Abstract]

SILBERBERGSINAKIN, I; Thorbecke, GJ; Baer, RL; Rosenthal, SA; Berezowsky, V
Clinical research 1976 ;24(3):A496-A496
ISI:A1976BU02801751  #29468  Click here for full text  

16.

"ANTIGEN-BEARING LANGERHANS CELLS IN DERMAL LYMPHATICS AND IN LYMPH-NODES" [Meeting Abstract]

SILBERBERGSINAKIN, I; Thorbecke, GJ; Baer, RL; Rosenthal, SA; Berezowsky, V
Journal of investigative dermatology 1976 ;66(4):276-276
ISI:A1976BN06400073  #29483  Click here for full text  

17.

"Dermal and intravascular Langerhans cells at sites of passively induced allergic contact sensitivity"

SILBERBERG I; Baer RL; Rosenthal SA; Thorbecke GJ; Berezowsky V
Cellular immunology 1975 Aug;18(2):435-453
MEDL:1139641  #8936  Click here for full text  10.1016/0008-8749(75)90071-4

18.

"LANGERHANS CELLS IN SKIN, LYMPHATIC-LIKE VESSELS AND DRAINING LYMPH-NODES IN ALLERGIC CONTACT SENSITIVITY" [Meeting Abstract]

SILBERBERG, I; Baer, RL; Rosenthal, SA; Thorbecke, GJ; Berezowsky, V
Clinical research 1975 ;23(3):A231-A231
ISI:A1975W188500380  #28654  Click here for full text  

19.

"Circulating Langerhans cells in a dermal vessel"

SILBERBERG I; Baer RL; Rosenthal SA
Acta dermato-venereologica 1974 ;54(2):81-85
MEDL:4133025  #16139  Click here for full text  

20.

"The role of langerhans cells in contact allergy. I. An ultrastructural study in actively induced contact dermatitis in guinea pigs"

SILBERBERG I; Baer RL; Rosenthal SA
Acta dermato-venereologica 1974 ;54(5):321-331
MEDL:4138800  #16138  Click here for full text